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. Author manuscript; available in PMC: 2015 Oct 2.
Published in final edited form as: N Engl J Med. 2015 Apr 2;372(14):1333–1341. doi: 10.1056/NEJMoa1406656

Table 1.

Observed and Counterfactual Changes in Global Deaths Due to Cardiovascular Diseases, 1990–2013.*

Disease Deaths in 1990 Deaths in 2013 Percentage Change, 1990–2013 Deaths Expected (2013 Population, 1990 Population Age Structure, 1990 Death Rates) Percentage Change from 1990 Due to Population Growth Deaths Expected (2013 Population, 2013 Population Age Structure, 1990 Death Rates) Percentage Change from 1990 Due to Population Aging Percentage Change from 1990 Due to Change in Age-Specific Death Rates
Ischemic heart disease 5,737,483 8,139,852 41.7 7,089,534 23.6 10,104,606 52.5 −34.4
Ischemic stroke 2,182,865 3,272,924 50.2 2,652,984 21.6 4,009,559 62.1 −33.5
Hemorrhagic stroke 2,401,931 3,173,951 30.7 3,046,620 26.8 4,475,353 59.5 −55.9
Hypertensive heart disease 622,148 1,068,585 74.1 804,870 29.5 1,201,735 63.6 −19.0
Cardiomyopathy and myocarditis 293,896 443,297 51.4 373,574 27.4 486,334 38.4 −14.2
Rheumatic heart disease 373,493 275,054 −26.5 493,302 31.8 653,518 42.8 −101.3
Aortic aneurysm 99,644 151,493 52.1 133,978 34.5 172,230 38.3 −20.7
Atrial fibrillation and flutter 28,916 112,209 288.1 39,136 35.4 52,484 46.2 206.5
Endocarditis 45,053 65,036 46.3 64,331 42.2 78,714 32.0 −28.8
Peripheral vascular disease 15,875 40,492 155.3 24,406 53.7 27,386 18.7 82.5
Other cardiovascular and circulatory diseases 478,261 554,588 15.2 638,716 33.7 852,357 44.9 −63.2
Total 12,279,565 17,297,480 40.8 15,361,450 25.1 22,114,276 55.0 −39.3
*

Decomposition6 of the observed number of cardiovascular deaths in 1990 and 2013 was used to calculate the contribution of three explanatory components: growth in the population, aging of the population, and change in the age-, sex-, and cause-specific rate of death. The age-, sex-, and cause-specific rate of death, which in this study is referred to as epidemiologic change, includes all changes in mortality that are not explained by demographic change (the aging or growth of the population) and includes the effect of both change in the prevalence of cardiovascular risk factors and access to health care. The sum of these three components is equal to the observed change in the total number of deaths.