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. 2015 Jun 22;8:1543–1552. doi: 10.2147/OTT.S77373

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© 2015 Lu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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THIO inhibits sphere formation and stemness genes expression.

Notes: (A) Morphology (left) and quantification (right) of sphere formation in HCC cell lines after treatments with DMSO as Control or THIO (10 μM). (B) Western blot analysis of CD133, EpCAM, and OCT4 expression in Huh7 and L02 cells after treatments with DMSO or THIO. (C) RT-PCR analysis for the stem cell markers in SNU449 and LM3 cells after treatments with DMSO or THIO. *P<0.05; **P<0.01; ***P<0.005.

Abbreviations: HCC, hepatocellular carcinoma; RT-PCR, real-time polymerase chain reaction; DMSO, dimethyl sulfoxide; THIO, thioridazine.