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. 2015 Jun 25;10(6):e0130739. doi: 10.1371/journal.pone.0130739

Table 3. Amino Acid Pathway.

Sub Pathway Biochemical Name FH/FN NBH/NBN AH/AN NBN/FN AN/FN AN/NBN
Glycine, Serine and Threonine Metabolism glycine 1.01 2.6 1.2 0.74 1.64 2.23
sarcosine (N-Methylglycine) 1.23 2.76 1.13 0.54 1.06 1.96
serine 0.95 1.66 1.36 0.86 1.42 1.65
threonine 1.07 1.7 1.13 1.14 2.19 1.93
Alanine and Aspartate Metabolism alanine 1.16 1.56 1.53 1.3 1.89 1.46
N-acetylalanine 1 0.77 1.44 1.6 1 0.62
aspartate 0.57 2.29 1.76 0.66 2.59 3.91
asparagine 1.52 0.92 0.96 1.55 2.34 1.51
Glutamate Metabolism glutamate 1.28 3.3 1.3 0.81 2.04 2.53
glutamine 1.12 1.55 1.11 1.49 4.18 2.81
gamma-aminobutyrate (GABA) 0.56 5.6 1.8 0.25 0.86 3.49
glutamate, gamma-methyl ester 2.02 4.15 1.18 1.17 1.58 1.35
Histidine Metabolism histidine 1.26 1.26 0.82 2.18 2.63 1.21
1-methylimidazoleacetate 1.52 2.7 2.37 1.63 2.15 1.32
Lysine Metabolism lysine 1.14 1.06 0.95 1.67 1.28 0.76
2-aminoadipate 1.26 3.36 1.14 1.29 3.7 2.86
Phenylalanine and Tyrosine Metabolism phenylalanine 1.22 1.19 0.79 1.54 3.26 2.12
tyrosine 1.2 1.56 1.07 1.42 2.64 1.85
p-cresol sulfate 0.65 0.85 0.7 1.09 3.23 2.97
3,4-dihydroxyphenethyleneglycol 1.03 2.07 2.47 0.78 7.81 10.01
Tryptophan Metabolism tryptophan 1.12 1.13 0.76 1.41 1.81 1.28
C-glycosyltryptophan* 0.93 1.67 1.21 0.77 2.07 2.69
Leucine, Isoleucine and Valine Metabolism leucine 1.17 1.29 0.94 1.45 3.13 2.17
isovalerylcarnitine 1.03 7.96 1.23 0.93 2.49 2.68
beta-hydroxyisovaleroylcarnitine 1.15 2.43 2.02 1.04 2.66 2.55
isoleucine 1.4 1.41 1.31 1.85 2.72 1.47
2-methylbutyrylcarnitine (C5) 0.91 2.48 0.86 0.87 1.64 1.89
valine 1.3 1.29 1.03 1.42 2.65 1.87
isobutyrylcarnitine 1.32 3.82 1 0.94 2.16 2.29
Methionine, Cysteine, SAM and Taurine Metabolism methionine 1.14 1.29 1.18 1.61 3.26 2.03
S-adenosylhomocysteine (SAH) 1.17 1.05 1.33 2.32 4.79 2.07
2-aminobutyrate 1.56 1.54 1.72 0.23 0.86 3.71
cysteine 1.33 0.63 0.81 1.76 3.93 2.23
hypotaurine 0.8 7.21 2.17 1.25 4.27 3.42
taurine 1.17 5.41 1.45 2.68 39.51 14.76
Urea cycle; Arginine and Proline Metabolism arginine 1.09 1.38 0.95 1.23 1.7 1.38
urea 1.37 0.73 1.64 1.13 2.87 2.55
ornithine 1.41 0.86 1.07 1.57 1.71 1.09
proline 0.86 1.11 1.33 1.27 0.72 0.56
citrulline 0.71 1.86 1.16 0.96 2.2 2.29
homocitrulline 1.56 1.8 1.82 0.1 0.31 3.27
dimethylarginine (SDMA + ADMA) 1.14 1.21 1.52 1.02 0.5 0.49
N-delta-acetylornithine* 0.81 1.04 1.59 0.1 0.3 3.11
N-methyl proline 0.97 0.76 0.3 2.05 3.33 1.63
trans-4-hydroxyproline 0.74 3 1.3 0.5 0.6 1.19
Creatine Metabolism creatine 0.93 2.85 1.42 0.96 3.4 3.54
Polyamine Metabolism putrescine 0.9 2.54 1.04 0.27 0.45 1.68
Glutathione Metabolism glutathione, reduced (GSH) 1.34 32.42 1.64 0.3 58.81 196.36
glutathione, oxidized (GSSG) 0.64 36.07 1.36 0.14 8.28 58.88
S-lactoylglutathione 1.15 2.17 1.36 0.98 1.78 1.82
cysteinylglycine 1.46 3.55 1.44 0.63 7.06 11.16
5-oxoproline 3.54 1.52 1.48 1.26 1.94 1.54
ophthalmate 1.07 1.7 0.94 0.43 5.69 13.12
S-nitrosoglutathione (GSNO) 1 1.16 1.53 1 2.85 2.85