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. 2015 Jun 25;10(6):e0130739. doi: 10.1371/journal.pone.0130739

Table 12. Top metabolites altered in newborn carotid arteries in response to LTH.

Biochemical Name NBH / NBN Biochemical Name NBH / NBN Biochemical Name NBH / NBN
glutathione, oxidized (GSSG) 36.07 cytidine 5'-monophosphate (5'-CMP) 2.92 2-oleoylglycerophosphoethanolamine* 0.59
glutathione, reduced (GSH) 32.42 creatine 2.85 1-palmitoylglycerophosphoinositol* 0.57
6-phosphogluconate 31.74 cyclic adenosine diphosphate-ribose 2.78 1-palmitoylglycerophosphocholine (16:0) 0.54
ascorbate (Vitamin C) 28.6 nicotinamide 2.78 1-oleoylglycerophosphoinositol* 0.54
3-phosphoglycerate 28.46 sarcosine (N-Methylglycine) 2.76 1-palmitoylglycerophosphoethanolamine 0.53
phosphoenolpyruvate (PEP) 25.46 mannitol 2.75 2-palmitoylglycerophosphoethanolamine 0.48
gamma-glutamylglutamate 8.22 gamma-glutamylphenylalanine 2.71 1-palmitoylplasmenylethanolamine* 0.48
phosphoethanolamine 8.15 1-methylimidazoleacetate 2.7 myristate (14:0) 0.46
isovalerylcarnitine 7.96 glycine 2.6 stearate (18:0) 0.46
malate 7.59 putrescine 2.54 palmitate (16:0) 0.44
hypotaurine 7.21 2-methylbutyrylcarnitine (C5) 2.48 docosapentaenoate (n6 DPA; 22:5n6) 0.43
pyrophosphate (PPi) 6.72 beta-hydroxyisovaleroylcarnitine 2.43 1-oleoylplasmenylethanolamine* 0.41
nicotinamide adenine dinucleotide reduced (NADH) 6.72 adenosine 5'-monophosphate (AMP) 2.35 linoleate (18:2n6) 0.41
pyruvate 6.47 pantothenate 2.22 15-methylpalmitate (isobar with 2-methylpalmitate) 0.4
lactate 6.1 glycerophosphorylcholine (GPC) 2.19 nonadecanoate (19:0) 0.39
gamma-aminobutyrate (GABA) 5.6 S-lactoylglutathione 2.17 arachidonate (20:4n6) 0.39
4-hydroxybutyrate (GHB) 5.58 3,4-dihydroxyphenethyleneglycol 2.07 2-oleoylglycerophosphoglycerol* 0.39
gamma-glutamylalanine 5.43 carnitine 2.04 1-stearoylglycerophosphoserine* 0.38
taurine 5.41 inosine 1.97 1-oleoylglycerophosphoserine 0.34
nicotinamide ribonucleotide (NMN) 5.33 3-ureidopropionate 1.96 1-oleoylglycerophosphoethanolamine 0.34
gamma-glutamylmethionine 4.96 butyrylcarnitine 1.93 erucate (22:1n9) 0.33
gamma-glutamylthreonine 4.62 cytidine-3'-monophosphate (3'-CMP) 1.9 dihomo-linoleate (20:2n6) 0.32
ribulose/xylulose 5-phosphate 4.35 adenosine 1.86 myristoleate (14:1n5) 0.32
fumarate 4.22 citrulline 1.86 17-methylstearate 0.31
nicotinamide adenine dinucleotide (NAD+) 4.22 methylphosphate 1.82 margarate (17:0) 0.3
erythronate 4.17 choline phosphate 1.7 docosatrienoate (22:3n3) 0.29
glutamate, gamma-methyl ester 4.15 threonine 1.7 cis-vaccenate (18:1n7) 0.28
glycerol 3-phosphate (G3P) 3.99 C-glycosyltryptophan 1.67 dihomo-linolenate (20:3n3 or n6) 0.28
beta-alanine 3.88 N-acetylneuraminate 1.65 5-HETE 0.28
isobutyrylcarnitine 3.82 3-dehydrocarnitine* 1.64 docosahexaenoate (DHA; 22:6n3) 0.27
acetylcarnitine 3.8 serylisoleucine* 1.61 eicosenoate (20:1n9 or 11) 0.27
cysteinylglycine 3.55 tyrosine 1.56 palmitoleate (16:1n7) 0.23
myo-inositol 3.37 alanine 1.56 docosapentaenoate (n3 DPA; 22:5n3) 0.23
2-aminoadipate 3.36 2-arachidonoylglycerophosphoethanolamine* 1.55 7-alpha-hydroxycholesterol 0.23
scyllo-inositol 3.31 1-stearoylglycerol (1-monostearin) 1.4 10-nonadecenoate (19:1n9) 0.21
glutamate 3.3 adenosine 5'-diphosphate (ADP) 1.39 10-heptadecenoate (17:1n7) 0.2
glycerol 2-phosphate 3.29 arginine 1.38 oleate (18:1n9) 0.2
carnosine 3.26 phosphate 0.85 mead acid (20:3n9) 0.2
propionylcarnitine 3.22 2-palmitoylglycerophosphocholine* 0.71 1-oleoylglycerol (1-monoolein) 0.19
sorbitol 3.19 1-palmitoylglycerophosphoglycerol* 0.7 stearidonate (18:4n3) 0.18
HEPES 3.1 pseudouridine 0.62 eicosapentaenoate (EPA; 20:5n3) 0.12
xylitol 3.02 pentadecanoate (15:0) 0.6 pentobarbital 0.01
trans-4-hydroxyproline 3 1-stearoylglycerophosphoethanolamine 0.55