FIG. 5.

Chamber volume to wall mass plus chamber volume ratio for HF vs. WT mice. (Symbol definitions are the same as in Figs. 3 and 4.) In HF mice this ratio is comparable to that in controls up to about week 17, but it quickly increases as a result of chamber dilatation and wall thinning. This marks a clear remodeling phase during which ventricular geometry is altered. Note the brief duration of the increase in this ratio over a <7-week span (weeks 15–22). Statistical significance refers to the difference in μl/(mg + μl) between the earliest and latest time points within each bracket for the entire HF data set (N = 4). HF vs. time: * P < 0.0001. NS: not statistically significant.