. Author manuscript; available in PMC: 2015 Jun 26.

Published in final edited form as: J Diabetes Obes. 2015 Feb 27;2(1):10.15436/2376-0494.15.007. doi: 10.15436/2376-0494.15.007

Table 2.

Frequency of NPC1 alleles and encoded residues in relation to race/ethnic group and total population

Alleles (Residues)	Non-Hispanic White (n=150)	Hispanic (n=353)	Native American (n=64)	Total Population (n = 567)
644A>G (H215R)
Major allele (A)^a	61	70	63	67
Minor allele (G)	39	30	37	33
1926C>G (I642M)
Major allele (C)	63^d	76^d	89^d	74
Minor allele (G)^b	37	24	11	26
2572A>G (I858V)
Major allele (A)^a	51^d	41^d	26^d	42
Minor allele (G)	49	59	74	58
3797G>A (R1266Q)
Major allele (G)^c	96^d	87^d	84^d	89
Minor allele (A)^c	4	13	16	11

NPC1 risk alleles (A) previously reported to be associated with morbid-adult obesity.

NPC1 risk allele (G) previously reported to be associated with diabetes independent of body weight.

NPC1 allele that has not been reported to be associated with either obesity or diabetes.

Significant differences (P<0.05) in frequency of the NPC1 alleles between non-Hispanic whites, Hispanic, and Native Americans using Pearson’s Chi square test.