Table 3.
Linkage-disequilibrium of NPC1 alleles and encoded residues in relation to race/ethnic group
Non-Hispanic White | (n=150) | |||
---|---|---|---|---|
R1266Q | I858V | I642M | ||
H215R | D′ | 0.9968 | 0.9996 | 0.9997 |
r2 | 0.0657 | 0.6557 | 0.9311 | |
P-value | 9.04E-06 | < 2.22E-16 | < 2.22E-16 | |
I642M | D′ | 0.9969 | 0.9996 | |
r2 | 0.0705 | 0.6109 | ||
P-value | 4.24E-06 | < 2.22E-16 | ||
I858V | D′ | 0.9962 | ||
r2 | 0.043 | |||
P-value | 0.0003 |
Hispanic | (n=353) | |||
---|---|---|---|---|
R1266Q | I858V | I642M | ||
H215R | D′ | 0.9994 | 0.9996 | 0.9996 |
r2 | 0.3535 | 0.2967 | 0.7543 | |
P-value | < 2.22E-16 | < 2.22E-16 | < 2.22E-16 | |
I642M | D′ | 0.9994 | 0.9993 | |
r2 | 0.4683 | 0.2238 | ||
P-value | < 2.22E-16 | < 2.22E-16 | ||
I858V | D′ | 0.9989 | ||
r2 | 0.1049 | |||
P-value | < 2.22E-16 |
Native American | (n=64) | |||
---|---|---|---|---|
R1266Q | I858V | I642M | ||
H215R | D′ | 0.9992 | 0.9992 | 0.9988 |
r2 | 0.3378 | 0.2013 | 0.2112 | |
P-value | 4.86E-11 | 3.87E-07 | 2.01E-07 | |
I642M | D′ | 0.9991 | 0.9971 | |
r2 | 0.6246 | 0.0424 | ||
P-value | < 2.22E-16 | 0.0198 | ||
I858V | D′ | 0.9982 | ||
r2 | 0.0679 | |||
P-value | 0.0031 |
D′ = Absolute linkage-disequilibrium estimate; r2 = Relative linkage-disequilibrium; P-value = Chi-square P-value for marker independence.