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. 2015 Jun 25;10(6):e0131038. doi: 10.1371/journal.pone.0131038

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© 2015 Nicoletti et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — The QQ-plot is constructed using the genotyped SNPs whose snp-map contains at least one ABC transporter pathway gene. The GSEA plot shows the enrichment score of the ABC transporter pathway. The top portion of the plot shows the running enrichment score for the pathway genes as the analysis moves down the ranked list. The peak score is the enrichment score for the gene set. The bottom portion of the plot shows the value of the ranking metric as it moves down the list of ranked genes. The plots for the other two enriched pathways (Proteasome and Propanoate metabolism) look similar (see S2 Fig).