Table 4. The top REACTOME pathways enriched in differentially expressed genes from SJS/TEN active lesions and ranked by FDR (FDR<0.25).
| Reactome Pathways | #GENES | PV | FE | FDR |
|---|---|---|---|---|
| DNA Replication | 11 | 0.0009 | 3.51 | 0.009 |
| Cell Cycle Checkpoints | 8 | 0.001 | 4.65 | 0.014 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 6 | 0.003 | 5.91 | 0.029 |
| Immune System | 22 | 0.003 | 1.91 | 0.029 |
| Proteasome mediated degradation of PAK-2p34 | 5 | 0.004 | 7.08 | 0.046 |
| Apoptosis (*) | 8 | 0.005 | 3.65 | 0.052 |
| Cell Cycle, Mitotic | 12 | 0.007 | 2.49 | 0.066 |
| HIV Infection | 9 | 0.008 | 3.06 | 0.074 |
| Signaling by Wnt | 5 | 0.01 | 5.31 | 0.121 |
The enrichment score is computed by DAVID on the 200 DEGs from Chung et al. Abbreviations: #GENES (number of DEGs in the pathway), PV (p-value, Fisher Exact test), FE (Fold Enrichment), FDR (false discovery rate). A (*) next to a pathway name indicates that the pathway was found to be enriched by both Pointer and DAVID.