Table 2. Univariate and multivariate Cox regression analysis of prognostic factors for overall survival in patients without distal metastases.
| Characteristics (N = 3388) | Univariate | Multivariate | ||
|---|---|---|---|---|
| P value | P value | HR (95% CI) | ||
| Age (years) ≥65 | <0.001 | <0.001 | 2.283 (1.912–2.725) | |
| Male | <0.001 | <0.001 | 1.407 (1.196–1.656) | |
| Rectal cancer | 0.044 | 0.001 | 1.318 (1.128–1.541) | |
| Primary tumor | Lymphovascular invasion | <0.001 | 0.006 | 1.334 (1.084–1.641) |
| Perineural invasion | <0.001 | 0.006 | 1.620 (1.149–2.286) | |
| High grade a | <0.001 | 0.005 | 1.368 (1.100–1.700) | |
| Pathologic staging | pT >2 | <0.001 | 0.011 | 1.292 (1.062–1.572) |
| pN+ | <0.001 | <0.001 | 1.661 (1.417–1.946) | |
| Preoperative serum CEA (ng/mL) level ≥10 | <0.001 | <0.001 | 1.568 (1.316–1.868) | |
| Visible PALNs (≥2 mm) | 0.015 | 0.094 | 1.198 (0.970–1.480) | |
aHigh grade represents poorly differentiated histology or mucinous carcinoma.
PALNs, para-aortic lymph nodes; CRC, colorectal cancer; HR, hazard ratio; CI, confidence interval; CEA, carcinoembryonic antigen