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. 2015 Jun 26;10(6):e0130872. doi: 10.1371/journal.pone.0130872

Table 2. Clinical and genetic features of WHO grade II gliomas (n = 417).

Characteristics IDH1 mutation (%) IDH1 wide-type (%) P-value
No. of cases 309(74) 108(26)
Gender (F/M) 128(41)/181 34(31)/73 0.078
Age (<40 / ≥40yrs) 187/125 52/55 0.041
Histopathology
    Astrocytomas 139(45) 49(45) 0.945
    Oligodendrogliomas 36(12) 11(10) 0.678
    Oligoastrocytomas 134(43) 48(44) 0.846
Tumor location
    Frontal lobe 224(72) 64(59) 0.010
    Temporal lobe 105(34) 45(42) 0.152
    Parietal lobe 23(7) 8(7) 0.288
    Insula 63(20) 23(21) 0.841
    Occipital lobe 6(2) 6(6) 0.110
    Others  20(6) 12(11) 0.119
Extent of resection
    GTR (%) 109(38)/176 44(45)/54 0.246
Molecular biomarkers
    MGMT promoter methylation (high/low) 42(65)/23 6(33)/12 0.017
    1p/19q loss (Yes/No) 89(30)/208 32(31)/71 0.834
    Mutant TP53 (Yes/No) 81(36)/145 7(9)/73 <0.001