Table 1. mRNA changes after sunitinib treatment in KURC1 and KURC2 xenograft tumors.
refseq | genedescription | genesymbol | KURC1R/C | KURC1S/C | KURC2S/C |
---|---|---|---|---|---|
NM_000640 | interleukin 13 receptor, alpha 2 | IL13RA2 | 6.50 | 0.99 | 1.45 |
NM_004686 | myotubularin related protein 7 | MTMR7 | 3.37 | 1.21 | 1.13 |
NM_021165 | family with sequence similarity 5, member B | FAM5B | 2.95 | 1.10 | 0.88 |
Microarray analysis was performed using Affymetrix GeneChip Human Gene 1.0 ST Arrays. These 3 genes were up-regulated more than 2.5-fold expression in sunitinib-resistant KURC1 tumor xenograft compared with control.