Fig. 3.

Sequential acquisition of DNA repair deficiency exclusively in LGG patients that were treated with TMZ and had a hypermutated recurrence. a Exome derived copy number status and germ-line variant allele frequency across chromosome 2 encompassing MSH2 and MSH6 in the initial and recurrent tumor of patient 18. b Methylation level of MGMT, mutations and copy number status of MGMT and MMR-related genes in initial LGG and paired recurrent tumors. The panel includes patients for whom exome sequencing data was available, * indicates samples with a proportion of tumor cells lower than 50%.