Fig 4. Effect of MNA treatment on exercise capacity in db/db mice.

Untreated db/db mice and db/db mice treated with MNA for 4 weeks were subjected to endurance running at 8 m·min^-1 on a treadmill with 5° inclination. The graph shows Kaplan-Meier curves of running mice in percentage for the two experimental groups: untreated mice (dashed line) and MNA-treated mice (solid line). Censored observations are marked with circles or triangles for the untreated and MNA-treated groups, respectively. Running time analysis was performed with Kaplan-Meier estimation using the log-rank Mantel-Cox test (n = 10–12).