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. 2015 Jun 26;10(6):e0131340. doi: 10.1371/journal.pone.0131340

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© 2015 Sonobe et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 1 — A) Schematic drawing of the water maze pool setting showing the location of platform and cues. Animals were placed at either of 3 entries of the pool. The annulus zone and the large circular area around the platform (PTF) were used to identify thigmotaxis, chaining or focal search as previously descried [54]. B) Swimming strategies used by the rats were classified in 8 categories (based on modified criteria proposed by Garthe et al. [54]) and were given a score from 0 to 7. Thigmotaxis, Random search and Scanning are regarded as spatial memory independent, or non-spatial strategies, while Directed, Focal, and Direct search were considered as spatial memory dependent. Chaining was scored separately. A score of 0 was given to the animals unable to swim. The traces are actual swimming patterns observed in our control rats.