Table 3. Predictors of change in CVD risk markers at 3 months.
| Δ TC (β(SE)) n 32 | p | Δ HDL-c (β (SE)) n 32 | p | Δ LDL-c (β (SE)) n 32 | p | Δ Trig (β (SE)) n 32 | p | Δ PWV (β (SE)) n 35 | p | Δ AIx (β (SE)) n 34 | p | Δ Syst BP (β (SE)) n 35 | p | Δ Diast BP (β (SE)) n 35 | p | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Δ CRP mg/L | -0.0 (0.0) | <0.001 | -0.0 (0.0) | 0.002 | -0.0 (0.00) | 0.02 | -0.0 (0.0) | 0.53 | -0.0 (0.0) | 0.30 | -0.1 (0.1) | 0.33 | -0.1 (0.1) | 0.07 | -0.0 (0.1) | 0.51 |
| Δ ESR mm/hour | -0.0 (0.0) | <0.001 | -0.0 (0.0) | 0.004 | -0.0 (0.0) | 0.004 | -0.0 (0.0) | 0.57 | 0.0 (0.0) | 0.90 | -0.1 (0.1) | 0.34 | -0.0 (0.1) | 0.79 | 0.0 (0.1) | 0.66 |
| Δ DAS28 | -0.3 (0.1) | 0.003 | -0.1 (0.1) | 0.01 | -0.2 (0.1) | 0.17 | -0.1 (0.1) | 0.28 | 0.1 (0.2) | 0.72 | 1.0 (1.0) | 0.32 | 3.4 (1.8) | 0.07 | 2.1 (1.0) | 0.06 |
| Δ USBM | -0.1 (0.0) | 0.01 | -0.0 (0.0) | 0.59 | -0.0 (0.0) | 0.02 | -0.0 (0.0) | 0.56 | -0.0 (0.0) | 0.29 | 0.1 (0.2) | 0.55 | 0.4 (0.3) | 0.17 | 0.4 (0.2) | 0.03 |
| Δ USPD | -0.0 (0.0) | 0.13 | -0.0 (0.0) | 0.73 | -0.3 (0.0) | 0.17 | -0.0 (0.0) | 0.50 | 0.0 (0.0) | 0.61 | -0.1 (0.2) | 0.76 | 0.6 (0.3) | 0.06 | 0.5 (0.2) | 0.04 |
| Rit vs Toc | -0.2 (0.3) | 0.49 | -0.1 (0.2) | 0.60 | -0.1 (0.3) | 0.76 | -0.1 (0.3) | 0.85 | 0.9 (0.4) | 0.02 | 0.8 (3.2) | 0.80 | 6.3 (5.0) | 0.22 | 4.0 (2.9) | 0.18 |
| Rit vs Aba | 0.4 (0.4) | 0.30 | -0.2(0.2) | 0.37 | 0.6 (0.3) | 0.05 | 0.0 (0.3) | 0.88 | -0.2 (0.5) | 0.60 | -0.7 (3.7) | 0.85 | -8.8 (5.8) | 0.14 | -6.6 (3.3) | 0.06 |
Linear regression Dependent variables: Change (Δ) in CVD risk markers at 3 months (Baseline values subtracted from 3-months values). Independent variables: Medication and change in disease activity at 3 months (Baseline values subtracted from 3-months values). β (SE) Regression co-efficient (Standard Error), n number, CRP: C-reactive protein mg/L ESR: Erythrocyte sedimentation rate mm/hour, TC: Total cholesterol mmol/L, HDL-c: High density lipoprotein cholesterol mmol/L, LDL-c: Low density lipoprotein cholesterol mmol/L, Trig: triglycerides, DAS28: Disease activity score 28 joints, USBM: Ultrasonography B-mode score, USPD: Ultrasonography Power doppler score, Syst BP: Systolic blood pressure mmHg, Diast BP: Diastolic mmHg blood pressure, AIx: Augmentation index %, PWV: Pulse wave velocity m/s, Rit: Rituximab, Toc: Tocilizumab, Aba: Abatacept.