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. 2015 Jun 26;10(6):e0131554. doi: 10.1371/journal.pone.0131554

Fig 1. Effects of motilin and ghrelin on gastric acid secretion.

Fig 1

In urethane-anaesthetized suncus, after a 60-min basal period, gastric acid secretion was measured after administration of histamine (1 mg/kg BW) (A), vehicle (B), ghrelin (0.1, 1.0, and 10 μg/kg BW) (C), motilin (0.1, 1.0, and 10 μg/kg BW) (D), and co-administration of motilin and ghrelin (E). Gastric acid secretion (blue line) and pH (red line) changes were monitored at 10-min intervals throughout the experiment. The net change in cumulative acid output for 50 min after each administration was also calculated (F). Each value represents the mean ± SEM. p < 0.05 was considered statistically significant. G: ghrelin; M: motilin, figures after the abbreviations denote concentration in μg/kg. n = 3–7.