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. 2015 Jun 26;10(6):e0131554. doi: 10.1371/journal.pone.0131554

Fig 2. Effects of famotidine on motilin, and co-administration of motilin and ghrelin-stimulated gastric acid secretion.

Fig 2

Gastric acid secretion was stimulated with histamine (1 mg/kg BW) (A, B), motilin (10 μg/kg BW) (D, E) and co-administration of motilin (10 μg/kg BW) and ghrelin (10 μg/kg BW) (G, H) with or without famotidine (0.33 mg/kg BW). In the left and middle panels, vehicle/famotidine was administrated intravenously 30 min before histamine (A, B), motilin (D, E) and co-administration of motilin and ghrelin (G, H). Gastric acid secretion (blue line) and pH (red line) changes were monitored at 10-min intervals throughout the experiment. Right panels represent the net change in cumulative acid output for 50 min after administration of histamine (C), motilin (F) and co-administration of motilin and ghrelin (I) with pre-administration of vehicle or famotidine. Each value represents the mean ± SEM. p < 0.05 was considered statistically significant. F: famotidine; G: ghrelin; M: motilin, figures after the abbreviations denote concentration in μg/kg. n = 3–4.