Table 1. Patient characteristics in the whole group and according to IL28 genotype.
| Characteristics | All patients | rs12979860 | rs8099917 | ||||
|---|---|---|---|---|---|---|---|
| CC | CT-TT | P value | TT | TG-GG | P value | ||
| N | 68 | 27 | 41 | 40 | 28 | ||
| Age (yr) | 34 (19–63) | 35 (19–60) | 34 (19–63) | 0.980 | 30 (19–60) | 41 (19–63) | 0.172 |
| Gender | |||||||
| Male | 56 (82.4%) | 21 (77.8%) | 35 (85.4%) | 33 (82.5%) | 25 (82.1%) | ||
| Female | 12 (17.6%) | 6 (22.2%) | 6 (14.6%) | 0.520 | 7 (17.5%) | 5 (17.9%) | 1.000 |
| HCV genotype | |||||||
| 1 | 57 (83.8%) | 22 (81.5%) | 35 (85.4%) | 32 (80.0%) | 25 (89.3%) | ||
| 4 | 11 (16.2%) | 5 (18.5%) | 6 (14.6%) | 0.743 | 8 (20.0%) | 3 (10.7%) | 0.505 |
| Fibrosis (F) stage | |||||||
| F0 | 5 (7.4%) | 3 (11.1%) | 2 (4.9%) | 4 (10.0%) | 1 (3.6%) | ||
| F1 | 31 (45.6%) | 12 (44.4%) | 19 (46.3%) | 17 (42.5%) | 14 (50.0%) | ||
| F2 | 23 (33.8%) | 9 (33.3%) | 14 (34.1%) | 0.726 1 | 14 (35.0%) | 9 (32.1%) | 0.931 1 |
| F3 | 7 (10.3%) | 3 (11.1%) | 4 (9.8%) | 4 (10.0%) | 3 (10.7%) | ||
| F4 | 2 (2.9%) | 0 (0.0%) | 2 (4.9%) | 1 (2.5%) | 1 (3.6%) | ||
| Activity (A) grade | |||||||
| A0 | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | ||
| A1 | 9 (13.2%) | 4 (14.8%) | 5 (12.2%) | 6 (15.0%) | 3 (10.7%) | ||
| A2 | 52 (76.5%) | 22 (81.5%) | 30 (73.2%) | 1.000 1 | 32 (80.0%) | 20 (71.4%) | 0.727 1 |
| A3 | 5 (7.4%) | 0 (0.0%) | 5 (12.2%) | 1 (2.5%) | 4 (14.3%) | ||
| A4 | 2 (2.9%) | 1 (3.7%) | 1 (2.4%) | 1 (2.5%) | 1 (3.6%) | ||
| Steatosis | 17 (25.0%) | 6 (22.2%) | 11 (26.8%) | 0.668 | 11 (27.5%) | 6 (21.4%) | 0.569 |
| ALT [IU/l] | 63 (14–214) | 74 (15–214) | 62 (14–179) | 0.295 | 69 (14–214) | 59 (24–179) | 0.404 |
| ALT > 40 | 51 (75.0%) | 19 (70.4%) | 32 (78.0%) | 0.474 | 29 (72.5%) | 22 (78.6%) | 0.569 |
| AST [IU/l] | 42 (11–157) | 47 (11–157) | 41 (21–123) | 0.210 | 44 (11–157) | 41.5 (21–123) | 0.513 |
| AST > 40 | 35 (51.5%) | 17 (63.0%) | 20 (48.8%) | 0.251 | 23 (57.5%) | 14 (50.0%) | 0.541 |
| GGTP [IU/l] (n = 58) | 45,5 (9–267) | 41 (9–158) | 46 (12–267) | 0.194 | 45.5 (9–267) | 45.0 (18–264) | 0.398 |
| GGTP > 60 | 25 (43.1%) | 8 (36.4%) | 17 (47.2%) | 0.418 | 13 (38.2%) | 12 (50.0%) | 0.373 |
| Cholesterol [mg/dl] | 166 (88–305) | 173 (110–305) | 162 (88–230) | 0.198 | 168 (88–305) | 165 (95–218) | 0.426 |
| Cholesterol > 200 | 12 (17.6%) | 8 (29.6%) | 4 (9.8%) | 0.075 | 10 (25.0%) | 2 (7.1%) | 0.101 |
1 P value for comparison of F0-1 and F2-4 or A0-1 and A2-4
All data are presented as median (min-max) or number (%); ALT, alanine aminotranferase; AST, aspartate aminotransferase; GGTP, gamma-glutamyl transpeptidase; A0-A4 and F0-F4, modified Scheuer scoring system.