Table I.
Characteristics of studies that assessed changes in BMI z-score during and after treatment in patients with pediatric ALL
| Author, Year (Location) |
N of Patients | Years at Diagnosis | Mean Age at Diagnosis (year) |
Treatment Protocol | % CRT | % Male | Mean BMI Z-score (SD) at Diagnosis |
|---|---|---|---|---|---|---|---|
| Odame et al, 1994 (United Kingdom) | 40 | 1980–1990 | 3.5 | MRC UKALL VIII and X | 100 | 47.5 | −0.006 (1.11) |
| Van Dogen-Melman et al, 1995 (Netherlands) | 113 | 1978–1990 | 3.8 | Dutch HR76, IIIB, V, VI, VI, VII | 46.0 | 51.3 | −0.50 (1.24) |
| Birkebaek et al, 1998 (a) (Denmark) | 33 | 1973–1984 | 4.3 | N/A | 66.7 | 42.4 | 0.35 (N/A) |
| Birkebaek et al, 1998 (b) (Denmark) | 30 | 1973–1984 | 4.3 | N/A | 60.0 | 50.0 | −0.64 (N/A) |
| Nysom et al, 1999 (Denmark) | 95 | 1970–1990 | 4.0 | N/A | 41.1 | N/A | −0.17 (0.85) |
| Reilly et al, 2000 (United Kingdom) | 98 | 1990–1997 | 5.2 | MRC UKALL-XI | N/A | 54.1 | −0.10 (1.06) |
| Sklar et al, 2000 (United States) | 126 | 1969–1982 | 6.4 | N/A | 69.8 | 46.8 | −0.18 (0.90) |
| Van der Sluis et al, 2002 (Netherland) | 61 | N/A | 7.1 | DCLSG-ALL9 | 0 | 61.0 | −0.29 (1.39) |
| Dalton et al, 2003 (United States) | 618 | 1987–1995 | 6.3 | DFCI ALL Consortium protocol 87-01 or 91-01 | N/A | 51.3 | −0.02 (1.30) |
| Davies et al, 2004 (United Kingdom) | 14 | N/A | 7.5 | MRC ALL 97 or the MRC ALL 97/99 | 0 | 50.0 | −0.33 (0.30) |
| Marinovic et al, 2005 (France) | 37 | 1995–1999 | 3.3 | EORTC 58881 | 0 | 54.1 | N/A |
| Baillargeon et al, 2007 (United States) | 307 | 1990–2002 | N/A | Multiple POG protocols | 0 | 60.6 | 0.22 (1.40) |
| Chow et al, 2007 (United States) | 165 | 1993–2003 | 4.8 | N/A | 19.4 | 57.0 | 0.24 (1.24) |
| Collins et al, 2010 (Canada) | 161 | 1985–2004 | 6.4 | DFCI protocols 85-01, 87-01, 91-01, 95-01, and 2000-01 | 60.0 | 61.0 | −0.20 (1.20) |
| Esbenshade et al, 2011 (United States) | 183 | 2000–2008 | 5.7 | COG | 12.6 | 61.7 | 0.64 (1.11) |
| Love et al, 2011 (Canada) | 102 | N/A | 3.3 | N/A | 7.8 | 46.1 | 0.12 (0.83) |
| Bang et al, 2012 (Korea) | 107 | 2005–2008 | 5.2 | Institutional protocol, CMCPL-2005 | 0 | 51.4 | 0.11 (1.03) |
| Karakurt et al, 2012 (Turkey) | 44 | 2000–2007 | 6.0 | BFM-95 | 59.0 | 57.0 | −0.25 (1.24) |
| Esbenshade et al, 2013 (USA) | 34 | 2008–2010 | N/A | COG | 26.5 | 64.7 | 0.52 (N/A) |
| Harper et al, 2013 (United Kingdom) | 77 | 1997–2003 | 4.6 | MRC/UKALL97 | 0 | 48.1 | 0.24 (1.16) |
| Zhang et al, 2014 (United States) | 83 | 1985–2010 | 4.0 | POG/DFCI/COG/others | 15.7 | 48.2 | 0.20 (1.20) |