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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Nat Neurosci. 2015 Jun 1;18(7):962–964. doi: 10.1038/nn.4034

Figure 1.

Figure 1

Stress–induced circuit specific synaptic adaptations. Two virus strategy for targeting of (a) ILT–vSTR and (e) PFC–vSTR projections. Confocal image of a single sagittal mouse slice of EYFP expressing (b) ILT–vSTR and (f) PFC –vSTR projection neurons (patterns examined in 3 mice per projection; scale bar =1mm, inset scale bar = 200 μm. Example traces (c,g) and quantification (d,h) of oEPSCs at −70 mV and +40 mV for ILT– (control/resilient/susceptible, n = 11/8/9cells, 4/3/3 mice, one–way ANOVA, * p = 0.014, F(2,25) = 5.075), and PFC–vSTR synapses (control/resilient/susceptible, n = 8/8/7 cells, 3/3/3 mice, one–way ANOVA, p = 0.524, F(2,20) = 0.268). Solid blue dots indicate the current amplitude used to calculate the AMPAR/NMDAR ratio. Scale bar: 100 pA, 100 ms. All error bars represent the s.e.m.