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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Psychopharmacology (Berl). 2015 Feb 24;232(14):2519–2530. doi: 10.1007/s00213-015-3886-1

Figure 6. Effect of genetic deletion of only the MT2 melatonin receptor on nicotine preference drinking.

Figure 6

Panel (A) shows nicotine consumption by nicotine concentration. No significant main effect of genotype was observed (F1, 64 = 0.03, p = 0.86), but there was a main effect of nicotine concentration (F4, 64 = 23.70, p < 0.0001). Panel (B) shows total nicotine consumption across the entire study, where no significant effect of genotype was observed (t = 0.18, df = 16, p = 0.86). As seen in panel (C) there were no significant main effects of nicotine concentration (F4, 64 = 0.93, p = 0.45) or genotype (F1, 64 = 0.21, p = 0.65) on total fluid consumption. Finally, in panel (D) there was no main effect of genotype (F1, 64 = 0.15, p = 0.70) on preference for the nicotine bottle, however there was a significant main effect of nicotine concentration (F4, 64 = 111.4, p < 0.0001). Values are presented as mean (SEM) and n = 10 control and 8 MT2 null mutant.