Table 2. Effect of melatonin supplementation on circadian parameters in C57 mice in 4-day bins.
Values obtained from non-orthogonal spectral analysis of home cage locomotor activity when data was combined into 4-days bins corresponding to the 4-day access to each concentration of nicotine. Values are presented as mean (SEM) and n = 15 control and 16 melatonin supplemented animals.
| Days | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1–4 | 5–8 | 9–12 | 13–16 | 17–20 | 21–24 | 25–28 | ||||||||
| Control | Melatonin | Control | Melatonin | Control | Melatonin | Control | Melatonin | Control | Melatonin | Control | Melatonin | Control | Melatonin | |
| Amplitude | 24.5 (4.8) | 26.6 (3.6) | 11.9 (1.6) | 12.7 (2.3) | 13.3 (2.7) | 12.9 (2.2) | 16.5 (3.2) | 16.4 (4.7) | 14.2 (3.5) | 14.2 (3.1) | 18.3 (4.2) | 12.5 (3.4) | 14.0 (2.6) | 13.0 (2.0) |
| SD Amplitude | 7.6 (0.5) | 7.9 (0.5) | 6.2 (0.3) | 6.2 (0.3) | 6.2 (0.4) | 6.2 (0.4) | 6.4 (0.4) | 6.3 (0.4) | 5.8 (0.3) | 6.1 (0.3) | 6.4 (0.5) | 6.4 (0.4) | 6.5 (0.4) | 6.8 (0.3) |
| Time of Nadir | 13.0 (1.3) | 14.9 (2.1) | 120.6 (2.1) | 122.8 (2.0) | 220.6 (1.7) | 221.4 (2.0) | 315.1 (2.3) | 303.5 (7.1) | 409.8 (1.4) | 411.3 (1.9) | 507.8 (1.9) | 504.3 (2. 1) | 605.8 (2.1) | 605.2 (2.0) |
| SD Time of Nadir | 3.4 (0.5) | 3.0 (0.4) | 4.7 (0.4) | 4.4 (0.5) | 4.6 (0.4) | 4.6 (0.5) | 4.6 (0.5) | 4.4 (0.5) | 4.4 (0.5) | 4.2 (0.5) | 4.1 (0.4) | 5.1 (0.5) | 4.1 (0.5) | 4.5 (0.4) |
| Time of Peak | 22.4 (1.3) | 22.0 (1.7) | 121.8 (1.4) | 125.1 (1. 8) | 217.7 (1. 8) | 219.9 (1.7) | 312.6 (2.0) | 312.3 (1.3) | 405.1 (1.9) | 407.2 (2.0) | 503.3 (2.1) | 507.6 (1. 8) | 599.5 (1.3) | 599.9 (1.2) |
| SD Time of Peak | 3.1 (0.5) | 2.8 (0.3) | 4.3 (0.5) | 5.0 (0.4) | 4.4 (0.5) | 4.3 (0.5) | 4.4 (0.6) | 4.8 (0.4) | 4.3 (0.5) | 4.2 (0.5) | 3.5 (0.5) | 5.2 (0.5) | 4.2 (0.4) | 4.5 (0.4) |