Figure 1. Aβ, NREM SWA, and memory retention measures in three sample subjects.

[¹¹C]PIB-PET DVR images demonstrating Aβ deposition (a), NREM SWA and associated localized slow wave source (b), proportion of NREM SWA 0.6–1Hz at FZ&CZ derivations (c), and overnight memory retention (long delay recognition testing – short delay recognition testing; d) measures in three sample participants with low mPFC PIB DVR (left column), intermediate mPFC PIB DVR (middle column), and high mPFC PIB DVR (right column). PIB-PET mPFC region of interest (ROI) is outlined in white (a) and the mPFC EEG derivations are outlined in black (b), with accompanying source analysis (thresholded at ±7) verifying mPFC overlap across PIB-PET and EEG ROIs (see Methods and Supplementary Fig. 2). Prop. denotes proportion, PIB denotes Pittsburgh compound B, PET denotes positron emission tomography, DVR denotes distribution volume ratio referenced against the whole cerebellum, mPFC denotes medial prefrontal cortex, and [HR–FAR–LR] denotes [hit rate to originally studied word pairs – false alarm rate to new, unstudied words – false alarm rate to originally studied word pairs].