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(a) Size distribution of lipid-PLGA hybrid NPs synthesized at different flow rates measured by dynamic light scattering (DLS). (b) Polydispersity index (PDI) of lipid-PLGA hybrid NPs by DLS. (c) TEM images of lipid-PLGA hybrid NPs synthesized at low (41 ml/h) and high (246 ml/h) flow rates. The inserted images clearly show the core-shell structure of hybrid NPs.
