Table 3.
Comparative drug resistance analysis of current protocol and ViroSeq™ genotypic resistance testing
| ViroSeq genotypic system | Whole genome sequencing | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
||||||||||
| PID | PI major | PI minor | NRTI-DRM | NNRTI-DRM | PI major | PI minor | NRTI-DRM | NNRTI-DRM | INT-DRM-major | INT-DRM-accessory | Co-receptor |
| SE600001 | None | None | None | None | None | None | None | None | None | None | CCR5 |
| SE600012 | None | None | None | None | None | None | None | None | None | None | CXCR4 |
| SE600023 | None | None | T215S | None | None | None | T215S | None | None | None | CCR5 |
| SE600034 | None | None | None | V90I | None | None | None | V90I | None | None | CCR5 |
| SE600035 | None | None | None | None | None | None | None | None | None | None | CCR5 |
| SE600046 | None | None | None | None | None | None | None | None | None | None | CXCR4 |
| SE600057 | None | None | None | None | None | V11I | None | None | None | E157Q | CCR5 |
| SE600063 | None | None | None | None | None | None | None | None | None | None | CXCR4 |
| SE600108 | None | None | None | None | None | None | None | N348I | None | None | CCR5 |
| SE600119 | None | None | None | None | None | None | None | None | None | None | CCR5 |
| SE600210 | None | None | None | None | None | None | None | None | None | None | CCR5 |
| SE600311 | None | None | None | V90I | None | None | None | V90I | None | None | CCR5 |
| SE600412 | None | None | None | None | None | None | None | None | None | None | CCR5 |
| SE600213 | None | None | None | None | None | None | None | None | None | None | CCR5 |
| SE600314 | None | L10IL | None | E138A | None | None | None | E138A | None | None | CCR5 |
| SE600415 | None | None | None | None | None | None | None | N348I | None | None | CCR5 |
| SE600122 | None | V11I | None | None | None | V11I | None | None | None | None | CCR5 |
| SE600516 | None | None | None | None | None | None | None | None | None | None | CCR5 |
| SE601017 | None | None | None | None | None | None | None | None | None | L74I | CXCR4 |
| SE601018 | None | None | None | E138A | None | None | None | E138A | None | None | CCR5 |
| SE601021 | None | None | None | None | None | None | None | None | None | None | CXCR4 |
| SE602019 | None | L10I, K20I | None | None | None | L10I, K20I | None | None | None | None | CCR5 |
| SE602020 | None | K20I | M184V | V106A, F227L, Y318FY | None | K20I | M184V | V106A, F227L | None | None | CXCR4 |
| SE602024 | None | K20I | None | None | None | K20I | None | None | None | None | CCR5 |
The mismatches are marked in bold.