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. 2014 Aug 1;17(1):81–94. doi: 10.1093/neuonc/nou144

Fig. 1.

Fig. 1.

Invasion of the subventricular zone (SVZ) by U87MG cells and GB138 primary cells after intrastriatal implantation. (A) Human GB138 cells specifically colonized the SVZ environment after migration through the corpus callosum (CC). (B) Human U87MG cells invaded the largest part of the right striatum 3 weeks after the graft. At this point, U87MG cells had already escaped the tumor mass (TM) and began to migrate along the CC (white arrows). (C) U87MG cells finally invaded the SVZ environment 4 weeks after the injection, with some of them still being in a proliferation state (white arrows, magnified square). (D) U87MG and GB138 cells isolated from the SVZ displayed stronger abilities to form gliomaspheres than U87MG or GB138 cells isolated from the TM. Human U87MG cells were detected using an antihuman nuclei antibody (Hu. Nuclei - red). GB138 cells were engineered to express the green fluorescent protein (eGFP - green). Cell nuclei were counterstained with DAPI (blue). Scale bars = 500 µm for B, 40 µm for A and C. ** P < .01, ***P < .001.