Fig. 3.

Activity of cabazitaxel and docetaxel in hedgehog-driven Smo/Smo spontaneous mouse medulloblastoma. MRI was performed prior to initiation of treatment to determine tumor volume and BBB integrity. Mice with tumors between 4 mm² and 16 mm² that lacked gadolinium contrast staining in the tumor were randomly enrolled into treatment groups. Enrolled mice received i.p. injections of cabazitaxel or docetaxel (15 mg/kg) on days 1, 3, and 5. MRI was repeated 3, 5, and 9 weeks after study enrollment with gadolinium contrast staining being included at weeks 5 and 9. (A) Mean tumor volume for each treatment group ± SEM. Tumor volume was calculated by 3-dimensional reconstruction of MR images. (B) Average mouse weight ± SEM as a percentage of the starting weight for each dosing group. (C) Survival of mice (group average ± SEM) from each treatment group.