Fig. 3.

MBZ markedly extended the survival of D425 xenograft medulloblastoma of group 3. (A) D425 medulloblastoma (MB) cells belong to group 3 of molecular classification and carry c-MYC and OTX2 genomic amplification. The cells were implanted into the right vermis of the cerebellum of nude mice. H&E staining demonstrated the fully grown cerebellar tumor. (B) Treatment by MBZ starting from day 5 of tumor implantation improved the median (m) survival from 21 to 48 days by 129%. (C) Xenogen scan demonstrated the inhibition of tumor growth after 12 days of MBZ treatment. The right graph shows the average xenogen counts without (Con) and with MBZ treatment.