Table 4.
Multivariate analysis for local control (LC), PFS, and OS
| Parameters | Hazard Ratios for LC (95% CI) | P | Hazard Ratios for PFS (95% CI) | P | Hazard Ratios for OS (95% CI) | P |
|---|---|---|---|---|---|---|
| Age, y | ||||||
| <36 vs ≥36 | 0.21 (0.10–0.43) | <.001 | 0.2 (0.1–0.39) | <.001 | 2.56 (0.73–8.61) | .13 |
| Initial treatment modality | ||||||
| Surgery alone | 1.0 | <.001a | 1.0 | <.001a | 1.0 | .73 |
| Surgery + standard-dose RT | 0.34 (0.15–0.77) | 0.34 (0.16–0.71) | 0.66 (0.16–2.70) | |||
| Surgery + high-dose RT | 0.28 (0.12–0.60) | 0.28 (0.14–0.57) | 0.55 (0.11–2.61) | |||
| Extent of surgery | ||||||
| GTR vs STR or biopsy | 2.08 (1.13–3.82) | .01 | 2.14 (1.38–4.24) | .02 | 2.70 (0.76–9.52) | .11 |
| Metastasis at diagnosis | ||||||
| Yes vs no | 1.35 (0.25–15.13) | .51 | 1.51 (0.19–11.48) | .69 | 6.0 (0.62–58.38) | .12 |
Abbreviation: STR, subtotal removal.
aSurgery vs surgery + standard-/high-dose RT.