Table 1.
Sample characteristics and clinical details by tumor location
| All (n = 282) | Supratentorial Brain n = 53 (19%) | Infratentorial Brain n = 100 (35%) | Spine n = 129 (46%) | |
|---|---|---|---|---|
| Age at diagnosis, y | ||||
| Mean (SD) | 44 (15) | 38 (13) | 47 (14) | 44 (15) |
| Range | 18–80 | 18–65 | 21–75 | 18–80 |
| Sex, n (%) | ||||
| Male | 143 (51) | 28 (53) | 53 (53) | 62 (48) |
| Female | 139 (49) | 25 (47) | 47 (47) | 67 (52) |
| Ethnicity, n (%) | ||||
| White non-Hispanic | 242 (86) | 49 (93) | 85 (85) | 108 (84) |
| Hispanic | 15 (5) | 2 (4) | 3 (3) | 10 (8) |
| Black | 12 (4) | 2 (4) | 7 (7) | 3 (2) |
| Asian | 4 (1) | 0 | 1 (1) | 3 (2) |
| Unknown | 9 (3) | 0 | 4 (4) | 5 (4) |
| Tumor grade, n (%) | ||||
| I | 30 (11) | 0 (0) | 0 | 30 (23) |
| II | 221 (78) | 32 (60) | 93 (93) | 96 (74) |
| III | 31 (11) | 21 (40) | 7 (7) | 3 (2) |
| Initial treatmenta, n (%) | ||||
| GTR | 161 (57) | 15 (28) | 51 (51) | 95 (74) |
| STR | 35 (12) | 6 (11) | 16 (16) | 13 (10) |
| STR + radiation | 55 (20) | 14 (26) | 23 (23) | 18 (14) |
| GTR + radiation | 31 (11) | 18 (34) | 10 (10) | 3 (2) |
| Initial radiation method, n (%) | ||||
| Conventional | 66 (77) | 26 (81) | 23 (70) | 17 (81) |
| IMRT | 13 (15) | 5 (16) | 7 (21) | 1 (5) |
| Radiosurgery | 1 (1) | 0 | 1 (3) | 0 |
| Missing | 6 (7) | 1 (3) | 2 (6) | 3 (14) |
| Initial Chemotherapyb, n (%) | 10 (4) n (%) | 7 (13) | 1 (1) | 2 (2) |
| Initial chemotherapy agents | ||||
| Alkylating | 7 (70) | 6 (86) | 0 | 1 (50) |
| ICE variation | 2 (20) | 1 (14) | 0 | 1 (50) |
| Missing | 1 (10) | 0 | 1 (100) | 0 |
| Initial chemotherapy cycles | ||||
| Median | 6 | 4 | – | 9 |
| Range | 3–12 | 3–6 | – | 6–12 |
| Median survival | Not reached | 7.8 | Not reached | Not reached |
| 5-year survival Rate | 87% | 62% | 85% | 97% |
| 5-year PFS Rate | 77% | 38% | 78% | 87% |
Abbreviations: GTR, gross total resection followed by observation; GTR + radiation, gross total resection followed by radiation; STR, subtotal resection followed by observation; STR + radiation, subtotal resection followed by radiation.
aInitial Treatment Variable is categorized as gross total resection followed by observation, subtotal resection followed by observation, subtotal resection followed by radiation, and gross total resection followed by radiation.
bChemotherapy either with or following radiation.