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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2015 May 21;35(7):1606–1615. doi: 10.1161/ATVBAHA.114.305228

Figure 6. Proposed mechanism for the role of PTK7+VEGFR2+ mononuclear cells in angiogenesis.

Figure 6

PTK7 expression by mononuclear cells is necessary for VEGFR2 acquisition in bone marrow and peripheral blood. These PTK7+VEGFR2+ mononuclear cells migrate to angiogenic sites where they promote angiogenesis by up-regulating ANG-1 secretion. Given their topographic localization and expression markers, they likely function in stabilizing blood vessel formation and/or have EPC potential.