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. 2015 Jun 11;8:67. doi: 10.1186/s13045-015-0164-y

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© Liu et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — SAE2 is essential for the migratory and invasive potential of SCLC cells in vitro. a Transwell invasion and migration assays of shCtrl-H446 and shSEA2 H446 tumor cells were performed. b The results are showed as an average of the number of migration/invasion cells from six random microscopic fields. c MMP2 and MMP9 protein level was measured by Western blot. Each data point represents mean ± SD of three independent experiments (***P < 0.001)