Table 2.
Demographic, haemodynamic and biochemical data
| Controls | ALMS | |
|---|---|---|
| Number n | 26 | 26 |
| Age years | 27 ± 6 | 27 ± 9 |
| Male n (%) | 17 (65 %) | 17 (65 %) |
| Height (m) | 1.74 ± 0.09 | 1.61 ± 0.09** |
| Weight (Kg) | 76 ± 16 | 77 ± 16 |
| Body Mass Index | 25 ± 4 | 30 ± 5** |
| Haemoglobin (g/dL) | 14.3 ± 1.2 | 14.0 ± 2.2 |
| eGFR (ml/min/1.73 m2) | 87 ± 8 | 73 ± 25* |
| Renin (pg/ml) a | - | 41 (18–153) |
| Aldosterone (pg/ml) a | - | 97 (67–220) |
| NT-pro BNP (ng/L) a | 38 (4–75) | 37 (17–89) |
| Cholesterol (mmol/L) | 4.6 (0.8) | 5.1 ± 1.3 |
| Triglycerides (mmol/L) a | 1.0 (0.6–1.4) | 2.5 (1.5–4.1)** |
| High Density Lipoprotein (mmol/L) | 1.4 (0.3) | 0.9 ± 0.3** |
| Glucose (mmol/L) a | 4.7 (4.2–5.0) | 6.1 (4.6–15.0)* |
| HbA1c (%) | - | 7.9 ± 2.7 |
| Insulin (pmol/L) a | - | 858 (239–1760) |
| C-peptide:Glucose ratio (ng/ml:mg/dl) a | - | 4.2 (2.2–6.2) |
| ACR (mg/mmol) a | 0.1 (0.05–0.2) | 1.5 (0.25–34) |
| Urate (mmol/L) | 286 ± 67 | 409 ± 111* |
| 24 h daytime SBP (mmHg) | 119 ± 9 | 130 ± 14* |
| 24 h daytime DBP (mmHg) | 72 ± 7 | 77 ± 9* |
ACR albumin/creatinine ratio, ALMS Alström Syndrome, DBP diastolic blood pressure, eGFR Estimated glomerular filtration rate, HBA 1c glycated haemoglobin, NT-pro BNP N-terminal pro B natriuretic peptide, SBP systolic blood pressure
Value ± standard deviation, amedian (inter-quartile range), p = * < 0.05, p = ** <0.01