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. 2015 Jul;185(7):1834–1845. doi: 10.1016/j.ajpath.2015.03.008

Figure 2.

Figure 2

Schematic diagram of ERG activation. ERG protein is activated with phosphorylation of serine residues 81 and 215 by AKT kinase. The activated ERG protein facilitates the transcription of Wnt/LEF1, MMP9, and CXCR4.