Table 3.
Fusion Transcripts that Result from Chromosome Rearrangement
| Fusion gene | Head gene locus | Tail gene locus | Fusion protein product |
|---|---|---|---|
| Chimera protein fusion | |||
| ALG5-PIGU∗ | 13q13.3 | 20q11.22 | ALG5(aa1-157)-PIGU(aa209-434) |
| PIGU-ALG5∗ | 20q11.22 | 12q13.3 | PIGU(aa1-208)-ALG5(aa158-294) |
| MAN2A1-FER | 5q21-22 | 5q21 | MAN2A1(aa1-703)-FER(aa572-822) |
| SLC45A2-AMACR | 5p13.2 | 5p13 | SLC45A2(aa1-187)-AMACR(aa84-394) |
| DDX5-ETV4∗ | 17q21 | 17q21 | DDX5(aa1-102)-ETV4(aa67-484) |
| HNRNPA2B1-ETV1 | 7p15 | 7p21.3 | HNRNPA2B1(aa1-2)-ETV1(aa16-477) |
| TMPRSS2-ETV5∗ | 21q22.2 | 3q28 | TMPRSS2(aa1-116)-ETV5(b) (aa1-510) |
| TMPRSS2 (aa1-18)-ETV5(a) (aa1-510) | |||
| Independent wild-type tail gene protein fusion | |||
| TMPRSS2-ERG(b) | 21q22.2 | 21q22.3 | TMPRSS2, CTT; ERG, WT |
| CCNH-C5orf30 | 5q13.3-14 | 5q21.1 | CCNH, CCT; C5orf30, WT |
| TNPO1-IKBKB∗ | 5q13.2 | 8p11.2 | TNPO1, CCT; IKBKB, WT |
| Non-chimera protein-forming fusion | |||
| TMPRSS2-ERG(a) | 21q22.2 | 21q22.3 | TMPRSS2, CTT; ERG, AWTASC |
| TMPRSS2-ETV1 | 21q22.2 | 7p21.3 | TMPRSS2, CTT; ETV1, AWTASC |
| TMPRSS2-ETV4 | 21q22.2 | 17q21 | TMPRSS2, CTT; ETV4, AWTASC |
| SLC45A3-ERG∗ | 1q32.1 | 21q22.3 | NK |
| SLC45A3-ETV5∗ | 1q32.1 | 3q28 | SLC45A3, AWTASC; ETV5, AWTASC |
| ACSL3-ETV1∗ | 2q34-35 | 7p21.3 | ACSL3, CTT; ETV1, AWTASC |
| HERV-K-ETV1∗ | 22q11.23 | 7p21.3 | HERV-K, CTT; ETV1, AWTASC |
| FLJ35294-ETV1 | 17p13.1 | 7p21.3 | FLJ35294, CTT; ETV1, AWTASC |
| FOXP1-ETV1∗ | 3p13 | 7p21.3 | FOXP1, CTT; ETV1, AWTASC |
| C15orf21-ETV1 | 15q21.1 | 7p21.3 | C15orf21, AWTASC; ETV1, AWTASC |
| KLK2-ETV4∗ | 19q13.33 | 17q21 | KLK2, CTT; ETV4, AWTASC |
| KLK2-ETV1 | 19q13.33 | 7p21.3 | KLK2, CTT; ETV1, AWTASC |
| CANT1-ETV4 | 17q25.3 | 17q21 | CANT1, CTT; ETV4, AWTASC |
| TMEM135-CCDC67 | 11q14.2 | 11q21 | TMEM135, CTT; CCDC67, AWTASC |
| LRRC59-FLJ60017 | 17q21.33 | 11q12.3 | LRRC59, CTT; FLJ60017, AWTASC |
| TRMT11-GRIK2 | 6q22.33 | 6q16.3 | TRMT11, CTT; GRIK2, AWTASC |
| MTOR-TP53BP1 | 1p36.2 | 15q15.21 | MTOR, CTT; TP53BP1, AWTASC |
| KDM4B-AC011523.1 | 19p13.3 | 19p12 | MTOR, CTT; tail gene unknown |
AWTASC, absence of wild-type ATG start codon; CCT, C-terminus truncation; NK, not known; WT, wild-type.
∗
Identified in only one case.