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. 2015 Jul;185(7):1944–1957. doi: 10.1016/j.ajpath.2015.03.024

Figure 3.

Figure 3

NADPH oxidase and peroxynitrite–driven NF-κB translocation and DNA-binding via Toll-like receptor (Tlr)-4 signaling. A: Results of NF-κB activation assay in murine samples of toxin-induced nonalcoholic steatohepatitis (NASH) model. NF-κB activation index (assessed from nuclear translocation and DNA binding of p65 subunit) is normalized against diet-induced obesity wild-type mouse (DIO) sample. B: Results of NF-κB activation assay in murine samples of diet-induced NASH model and human samples. NF-κB activation index is normalized against appropriate and respective control samples. ∗P < 0.05. BCDM, bromodichloromethane.