Table 3.

Numbers of responders and nonresponders for each primary outcome and statistically significant baseline parameters (responder analysis)

	Responders	Nonresponders	p
MMSE, n	42	53
Intervention type, n
CI	21	11	0.011, uncorrected
PA	8	16
GRA	13	26
MMSE score	22.4 ± 2.5	24.8 ± 3.0	<0.001, uncorrected
QOL, n	35	60
Education, years	9.4 ± 1.9	8.4 ± 1.4	<0.005, uncorrected
WF, n	36	59
TMT-A, n	35	60
6-meter walk, n	33	62

Mean ages, mean years of education, mean scores of the GDS and baseline values of all primary outcomes (MMSE, WF, TMT-A, 6-meter walk time and QOL Face Scale) were compared between the responders and nonresponders. For each outcome measure, responders were defined as subjects who showed improvement that was equal to or greater than the cutoff point.

Better improvement in MMSE and QOL Face Scale scores correlated with lower baseline MMSE score (p < 0.001) and more years of education (p < 0.005), respectively. A weak but nonsignificant effect of the type of intervention was found for the outcome of the MMSE (p = 0.011).