Table 2.

Risk factors associated with therapeutic response to first-generation direct acting antivirals in patients previously treated with pegylated interferon and ribavirin

	SVR rates (%)
	Boceprevir			Telaprevir
Predictive variables	PR48	BOCRGT	BOCPR48	PR48	T12PR48
Previous relapser	29	69	75	24	83
Previous partial-responder	7	40	52	15	59
Previous null responder				5	29
Mild-moderate fibrosis	23	63	68	16	76
Advanced fibrosis	13	44	68	11	49
Black race	8	61	63	10	55
HCVRNA viral load > 800.000 IU/mL (baseline)
IL28B C/C	46	79	77	29	79
Il28B C/T	17	61	73	16	60
IL28B T/T	50	55	72	13	61
HCV genotype 1a	24	5	61
HCV genotype 1b	22	65	73
BMI < 25	20	6	68
BMI ≥ 30	11	56	65
Relapse	15	59	54

Data obtained, analyzed and adapted from Ref. [40,41,44,45]. PR48: Standard therapy with pegylated interferon plus ribavirin for 48 wk; BOCRGT: Boceprevir with therapy possibly shortened by response guided therapy; BOCPR48: Boceprevir with treatment fixed time for 48 wk; T12PR48: Telaprevir by 12 wk and standard therapy for 48 wk; IL28B: Interleukin-28B; BMI: Body mass index; HCV: Hepatitis C virus; SVR: Sustained virologic response.