Table 3.
MicroRNAs with potential prognostic impact in patients with hepatocellular carcinoma
| MiRNAs | Molecular alteration | Clinical significance | Ref. |
| 20 miRNAs | Signature | Venous metastasis, overall survival | [154] |
| 19 mi NAs | Signature | Poor survival | [155] |
| MiR-19a, miR-886-5p, miR-126, miR-233, miR-24, and miR-147 | Signature | Predictor of overall survival and recurrence-free survival after LT | [156] |
| MiR-26a | Down-regulation | Poor survival | [157] |
| MiR-122 | Down-regulation | Gain of metastasis properties | [158,159] |
| MiR-122 | Down-regulation | Early recurrence | [160] |
| Let-7 members | Down-regulation | Early recurrence | [161] |
| MiR-199a-3p | Down-regulation | Reduced time to recurrence | [162] |
| MiR-199b-5p | Down-regulation | Poor overall survival and progression-free survival rates | [163] |
| MiR-101 | Down-regulation | Advanced tumour progression, poor prognosis | [164] |
| MiR-125a | Up-regulation | Better survival | [165] |
| MiR-92, miR-20, miR-18 | Up-regulation | Poor differentiation | [166] |
| MiR-372 | Up-regulation | Advanced TNM stage | [167] |
| MiR-221 | Up-regulation | Multi-nodularity, reduced time to recurrence | [168] |
| MiR-221 | Up-regulation | Gain of metastatic properties | [169] |
| MiR-221 | Up-regulation | High tumour capsular infiltration | [170] |
| MiR-17-5p | Up-regulation | Multiple tumour nodules, vein invasion, shortened overall survival | [171] |
| MiR-155 | Up-regulation | High recurrence and poor prognosis following OLT | [172] |
| MiR-203 | Up-regulation | Good prognosis | [173] |
| MiR-18 | Up-regulation | Poor prognosis | [174] |
Data adapted from Negrini et al[175]. MiRNAs: MicroRNAs; TNM: Tumour-node-metastasis; LT: Liver transplantation; OLT: Orthotopic liver transplantation.