Table 3.
Association of categories of time-averaged uncorrected serum calcium with all-cause, cardiovascular, and infection-related mortality in patients treated with PD or HD (PD, n=10,066; HD, n=118,955)
| Uncorrected Serum Calcium (mg/dl) | Adjusted Hazards Ratio (95% CI)a | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| All-Cause Mortality | Cardiovascular Mortality | Infection-Related Mortality | |||||||
| Unadjusted | Case Mixb | Case Mix+Albuminc | Unadjusted | Case Mixb | Case Mix+Albuminc | Unadjusted | Case Mixb | Case Mix+Albuminc | |
| Patients on PD | |||||||||
| <8.5 | 1.69 (1.54 to 1.87) | 2.00 (1.81 to 2.21) | 1.29 (1.16 to 1.44) | 1.57 (1.35 to 1.83) | 1.81 (1.55 to 2.11) | 1.21 (1.03 to 1.43) | 1.86 (1.5 to 2.31) | 2.15 (1.72 to 2.67) | 1.31 (1.04 to 1.65) |
| 8.5 to <9.0 | 1.36 (1.26 to 1.48) | 1.35 (1.24 to 1.47) | 1.10 (1.01 to 1.20) | 1.33 (1.67 to 1.51) | 1.29 (1.14 to 1.47) | 1.08 (0.95 to 1.23) | 1.48 (1.23 to 1.78) | 1.56 (1.21 to 1.76) | 1.16 (0.96 to 1.41) |
| 9.0 to <9.5 | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| 9.5 to <10.2 | 0.82 (0.75 to 0.89) | 0.90 (0.83 to 0.98) | 1.06 (0.97 to 1.15) | 0.75 (0.66 to 0.85) | 0.86 (0.75 to 0.97) | 0.99 (0.87 to 1.13) | 0.83 (0.69 to 0.99) | 0.90 (0.75 to 1.08) | 1.09 (0.90 to 1.31) |
| ≥10.2 | 1.09 (0.94 to 1.26) | 1.35 (1.17 to 1.57) | 1.65 (1.42 to 1.91) | 0.93 (0.74 to 1.17) | 1.21 (0.95 to 1.53) | 1.45 (1.15 to 1.84) | 1.05 (0.76 to 1.45) | 1.23 (0.89 to 1.71) | 1.56 (1.13 to 2.17) |
| Patients on HD | |||||||||
| <8.5 | 1.74 (1.69 to 1.78) | 2.02 (1.96 to 2.07) | 1.17 (1.13 to 1.20) | 1.57 (1.50 to 1.64) | 1.82 (1.75 to 1.9) | 1.18 (1.13 to 1.23) | 1.97 (1.85 to 2.10) | 2.27 (2.13 to 2.41) | 1.15 (1.08 to 1.23) |
| 8.5 to <9.0 | 1.39 (1.36 to 1.42) | 1.38 (1.35 to 1.41) | 1.12 (1.09 to 1.14) | 1.35 (1.30 to 1.39) | 1.32 (1.28 to 1.37) | 1.12 (1.08 to 1.16) | 1.48 (1.40 to 1.55) | 1.47 (1.40 to 1.55) | 1.14 (1.08 to 1.20) |
| 9.0 to <9.5 | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| 9.5 to <10.2 | 0.83 (0.82 to 0.85) | 0.90 (0.88 to 0.92) | 1.03 (1.00 to 1.05) | 0.86 (0.84 to 0.89) | 0.94 (0.91 to 0.98) | 1.05 (1.02 to 1.09) | 0.82 (0.78 to 0.86) | 0.86 (0.82 to 0.91) | 1.00 (0.95 to 1.06) |
| ≥10.2 | 1.21 (1.17 to 1.26) | 1.39 (1.34 to 1.44) | 1.59 (1.53 to 1.65) | 1.26 (1.19 to 1.33) | 1.46 (1.39 to 1.55) | 1.64 (1.55 to 1.73) | 1.17 (1.08 to 1.28) | 1.25 (1.15 to 1.37) | 1.47 (1.34 to 1.60) |
Reference group: patients on PD with uncorrected calcium between 9.0 and <9.5 mg/dl for analyses in patients on PD; reference group: patients on HD with uncorrected calcium between 9.0 and <9.5 mg/dl for analyses in patients on HD.
Data adjusted for age, sex, diabetes, race and/or ethnicity, primary insurance, marital status, dialysis vintage category (<6 months, 6 months to 2 years, 2–5 years, and >5 years), body mass index, atherosclerotic heart disease, cancer, congestive heart failure, other cardiac diseases, cerebrovascular disease, peripheral vascular disease, chronic obstructive pulmonary disease, and tobacco smoking.
Data adjusted for the demographic characteristics above plus serum albumin.