Table 5.
Association of quartiles of time-averaged serum phosphorus with all-cause, cardiovascular, and infection-related mortality in patients treated with PD or HD (n=129,042)
| Serum Phosphorus (mg/dl) | Adjusted Hazards Ratio (95% CI) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| All-Cause Mortality | Cardiovascular Mortality | Infection-Related Mortality | |||||||
| Unadjusted | Case Mixa | Case Mix+Albuminb | Unadjusted | Case Mixa | Case Mix+Albuminb | Unadjusted | Case Mixa | Case Mix+Albuminb | |
| Patients on PD | |||||||||
| <4.5 | 1.40 (1.29 to 1.52) | 1.19 (1.09 to 1.29) | 1.04 (0.95 to 1.13) | 1.40 (1.23 to 1.59) | 1.16 (1.02 to 1.32) | 1.02 (0.89 to 1.16) | 1.28 (1.07 to 1.53) | 1.09 (0.91 to 1.30) | 0.92 (0.77 to 1.10) |
| 4.5 to <5.4 | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| 5.4 to <6.4 | 0.90 (0.82 to 0.98) | 1.09 (1.00 to 1.20) | 1.09 (1.00 to 1.19) | 0.97 (0.84 to 1.11) | 1.19 (1.04 to 1.37) | 1.19 (1.03 to 1.36) | 0.79 (0.65 to 0.96) | 0.92 (0.76 to 1.13) | 0.93 (0.77 to 1.14) |
| ≥6.4 | 0.88 (0.81 to 0.97) | 1.52 (1.38 to 1.68) | 1.48 (1.34 to 1.63) | 1.00 (0.87 to 1.16) | 1.77 (1.53 to 2.06) | 1.73 (1.49 to 2.01) | 0.88 (0.72 to 1.08) | 1.42 (1.15 to 1.75) | 1.39 (1.13 to 1.72) |
| Patients on HD | |||||||||
| <4.5 | 1.39 (1.36 to 1.42) | 1.23 (1.20 to 1.26) | 1.09 (1.06 to 1.11) | 1.32 (1.28 to 1.37) | 1.17 (1.13 to 1.21) | 1.06 (1.02 to 1.10) | 1.45 (1.38 to 1.53) | 1.30 (1.24 to 1.38) | 1.11 (1.05 to 1.17) |
| 4.5 to <5.4 | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| 5.4 to <6.4 | 0.91 (0.89 to 0.93) | 1.09 (1.06 to 1.11) | 1.12 (1.09 to 1.15) | 0.95 (0.92 to 0.99) | 1.14 (1.10 to 1.18) | 1.17 (1.13 to 1.21) | 0.93 (0.88 to 0.99) | 1.09 (1.03 to 1.16) | 1.14 (1.08 to 1.20) |
| ≥6.4 | 0.90 (0.88 to 0.93) | 1.47 (1.43 to 1.50) | 1.50 (1.47 to 1.54) | 0.99 (0.96 to 1.02) | 1.64 (1.58 to 1.70) | 1.67 (1.61 to 1.73) | 0.95 (0.90 to 1.01) | 1.49 (1.40 to 1.57) | 1.54 (1.46 to 1.63) |
a
Data adjusted for age, sex, diabetes, race and/or ethnicity, primary insurance, marital status, dialysis vintage category (<6 months, 6 months to 2 years, 2–5 years, and >5 years), body mass index, atherosclerotic heart disease, cancer, congestive heart failure, other cardiac diseases, cerebrovascular disease, peripheral vascular disease, chronic obstructive pulmonary disease, and tobacco smoking.
b
Data adjusted for the demographic characteristics above plus serum albumin.