Figure 1.

High salt induces renal inflammation, fibrosis, sympathetic activation, and oxidative stress in 5/6Nx rats. (A) Representative photographs of macrophage (ED-1–positive cells) infiltration and renal fibrosis (shown by PAS or Masson staining). (B–D) Quantitative analysis of macrophage infiltration (B), glomerulosclerosis index (C), and tubulointerstitial fibrosis score (D). (E) Changes in SBP. (F) Changes in UAE. (G) Concentration of NE in renal cortex. (H–I) Protein (H) and mRNA (I) levels of Noxs in renal cortex. Data from three independent experiments are expressed as the mean±SD (n=6 in each group). *P<0.05 versus normal salt in the respective group. HS, high salt; LS, low salt; NS, normal salt; PAS, periodic acid–Schiff.