. 2015 Jan 29;26(7):1619–1633. doi: 10.1681/ASN.2014050518

Table 1.

Changes in biochemical and metabolic parameters

Parameter	Sham Rats			5/6Nx Rats
Parameter	Low Salt	Normal Salt	High Salt	Low Salt	Normal Salt	High Salt
Body wt (g)
0 wk	453±9	466±10	468±12	456±10	461±9	459±11
2 wk	491±11	494±13	495±12	484±12	485±18	482±15
Kidney wt/body wt (mg/g)	3.2±0.1	3.2±0.2	3.1±0.1	4.2±0.1^a	4.4±0.2^a	4.8±0.2^a^,^b
Serum creatinine (μmol/L)
0 wk	68±4	71±5	72±3	107±5^a	111±6^a	112±3^a
2 wk	66±4	72±4	75±8	110±6^a	114±6^a	117±9^a
Serum Na⁺ (mmol/L)
0 wk	140±3	138±3	140±3	139±2	140±3	140±2
2 wk	140±3	140±1	142±2	141±3	141±2	144±2^a^,^b
Urine volume (ml/24 h)
0 wk	29±2	30±2	31±3	29±3	28±3	27±3
2 wk	25±3^b	32±4	40±8^b	20±4	26±4	59±9^a^,^b
Urine Na⁺ (mmol)
0 wk	0.83±0.16	0.85±0.16	0.83±0.19	0.79±0.14	0.78±0.19	0.77±0.15
2 wk	0.13±0.08^b	0.87±0.79	15.32±0.19^b	0.10±0.07^b	0.75±0.13	10.94±0.14^a^,^b
Plasma renin activity (ng AngI/ml per h)
0 wk	4.9±0.7	5.2±0.5	5.0±0.4	2.3±0.2^a	2.5±0.2^a	2.2±0.3^a
2 wk	8.2±0.7^b	5.1±0.4	3.0±0.3^b	3.2±0.3^a^,^b	1.4±0.2^a	0.5±0.1^a^,^b
Plasma AGT (ng/ml)
0 wk	3222±274	3149±332	3188±320	2932±245	3005±329	2878±277
2 wk	3474±131^b	3277±154	3049±118^b	3256±148^a^,^b	2990±136^a	2712±150^a^,^b
Serum ACE-1 activity (nmol/ml per min)
0 wk	86±3	87±4	89±5	84±3	85±2	83±4
2 wk	90±6	86±4	88±3	87±2	86±2	80±3^a^,^b
Plasma AngII (pg/ml)
0 wk	36±4	40±5	38±3	27±4^a	30±3^a	29±3^a
2 wk	81±5^b	47±3	25±3^b	58±3^a^,^b	28±2^a	15±2^a^,^b
Plasma NE (pg/ml)
0 wk	301±20	312±19	293±16	647±26^a	635±42^a	651±38^a
2 wk	442±37^b	335±18	253±21^b	551±22^a^,^b	671±38^a	822±31^a^,^b

Data from three independent experiments are expressed as the mean±SD (n=6 in each group).

P<0.05 versus sham group fed with the same salt diet.

P<0.05 versus rats fed with normal salt in the sham or 5/6Nx group.