Table 5.
Incidence of rejection by time interval
| Classes of Biopsies | Number of Biopsies in Each Interval (Percentage of Total for Interval) | Total | |||||
|---|---|---|---|---|---|---|---|
| Early | Intermediate: 1–5 yr (366–1825 d) | Late | |||||
| 0–7 d | 8 d to 6 mo (8–180 d) | 6–12 mo (181–365 d) | 5–10 yr (1826–3650 d) | >10 yr (>3650 d) | |||
| n | 16 | 213 | 69 | 190 | 105 | 110 | 703 |
| Biopsies of kidneys that progressed to failure | 1 (6) | 18 (8) | 9 (13) | 62 (33) | 33 (31) | 45 (41) | 168 |
| Biopsies with rejection | |||||||
| Conventional pure TCMR | 1 (6) | 41 (19) | 11 (16) | 10 (5) | 3 (3) | 1 (1)a | 67 |
| Molecular pure TCMRb | 1 (6) | 42 (20) | 15 (22) | 18 (9) | 0 (0) | 0 (0) | 76 |
| Conventional pure ABMR | 2 (13) | 5 (2) | 2 (3) | 44 (23) | 29 (28) | 28 (25) | 110 |
| Molecular pure ABMR | 0 (0) | 7 (3)c | 3 (4)c | 41 (22) | 39 (37) | 34 (31) | 124 |
| Conventional mixed | 0 (0) | 2 (1) | 1 (1) | 11 (6) | 11 (10) | 3 (3)d | 28 |
| Molecular mixed | 0 (0) | 5 (2) | 6 (9) | 11 (6) | 5 (5) | 1 (1)d | 28 |
a
One conventional pure TCMR at day 3878 (with heavy scarring that may have obscured ABMR lesions) and two conventional mixed at days 4445 and 5989 were considered to have TCMR activity caused by isolated v lesions, which may be because of pure ABMR. All had negative TCMR scores and positive ABMR scores.
b
Positive TCMR score>0.1; positive ABMR score>0.2.
c
Some positive ABMR scores before 1 year occurred in biopsies from patients who were donor-specific HLA antibody-negative with no conventional evidence of ABMR activity and may reflect ABMR-like molecular changes in other diseases.
d
One biopsy at 3717 days (10.2 years) with conventional and molecular mixed rejection was the last with a positive TCMR score.