Table 6.
Molecular findings in 28 biopsies with a conventional diagnosis of mixed rejection
| Discrepancies | 0–7 d | 8 d to 6 mo (8–180 d) | 6–12 mo (181–365 d) | 1–5 yr (366–1825 d) | 5–10 yr (1826–3650 d) | >10 yr (>3650 d) |
|---|---|---|---|---|---|---|
| Number in interval | 0 | 2 | 1 | 11 | 11a | 3a |
| Number of biopsies of kidneys that progressed to failure | 0 | 0 | 1 | 5 | 6 | 0 |
| Classification by molecular scores | ||||||
| Pure TCMR (ABMR score negative TCMR score positive) | 0 | 0 | 1 | 3 | 0 | 0 |
| Pure ABMR (ABMR score positive; TCMR score negative) | 0 | 1 | 0 | 3 | 10 | 2 |
| Mixed (ABMR and TCMR scores positive) | 0 | 0 | 0 | 4 | 1 | 1 |
| No rejection (ABMR and TCMR scores negative) | 0 | 1 | 0 | 1 | 0 | 0 |
a
As discussed in the text, 5 of 11 mixed biopsies from 5 to 10 years and 2 of 3 mixed biopsies in >10 years with negative TCMR scores were diagnosed conventionally as having TCMR activity only on the basis of isolated v lesions, which can occur in pure ABMR. The others had tubulitis, which can occur in various progressive renal diseases.