Table 2.
Examples of common Class I cross–reactive (public) epitope groups
| CREG | Antigens Included |
|---|---|
| A1 | A1, 3, 11, 29, 30, 31, 36,8 0 |
| A2 | A2, A9(23,24), A28(68,69), B17(57,58) |
| A10,19 | A10(25,26,34,66) A19 (29,30,31,32,33,42,74) |
| B12 | B12(44,45), B13, B21(49,50), B40(60,61), 41, B47 |
| B5,18 | B5(B51, 52), 18, 35, 53, 78 |
| B8 | B8, B16(38,39), B14(64, 65) |
| B15 | B62, 63, 71, 72, 75, 76, 77 |
| B7 | B7, 13, B22(54,55,56), 27, 42, 47, 67, 73, 81 |
| BW6 | B7,a 8,a 14, 15,a 16, 18, 22, 35, 39, 40,a 41, 42, 45, 46, 48, 50, 54, 55, 56,a 60, 61, 62, 64, 65, 67, 70, 71, 72, 75, 76, 78, 79, 81, 82 |
| BW4 | A9, 23, 24, 25, 32, B13,b 27,b 37, 38, 44,b 47,b 49, 51, 52, 53, 57, 58, 59, 63 |
Common cross–reactive epitope groups (CREGs) are listed with HLA antigens that belong to each group.149,150 Recognition of these patterns of antibodies is important in antibody analysis. Antibodies to epitopes shared among CREG members may be diluted across multiple beads, leading to lower individual bead MFI.
a
Exceptions: B*07:27, B*08:02, B*08:03, B*40:13, B*40:19, B*56:07, and select B*15 alleles are in the Bw4 group.
b
Exceptions: B*13:09, B27:08, B*27:12, B*27:18, B*44:09, and B*47:02 are in the Bw6 group.