Table 1.
Effects of U, HU and cholestyramine on serum lipid profiles in rats supplemented with a cholesterol-rich diet.
| Group | Dose (mg/kg) | TC (mmol/L) | TG (mmol/L) | LDL-C (mmol/L) | HDL-C (mmol/L) |
|---|---|---|---|---|---|
| Male | |||||
| Normal control | - | 1.69 ± 0.15 | 0.87 ± 0.13 | 0.49 ± 0.03 | 1.04 ± 0.04 |
| Hyperlipidemia | - | 2.21 ± 0.25 Δ | 1.23 ± 0.11 Δ | 0.70 ± 0.04 Δ | 0.82 ± 0.13 Δ |
| U | 250 | 1.34 ± 0.35 * | 0.85 ± 0.05 | 0.41 ± 0.01 * | 0.81 ± 0.05 |
| HU (low dose) | 125 | 1.34 ± 0.06 * | 0.79 ± 0.02 | 0.41 ± 0.02 * | 0.88 ± 0.02 |
| HU(middle dose) | 250 | 1.30 ± 0.10 ** | 0.72 ± 0.14 * | 0.43 ± 0.05 | 0.93 ± 0.13 |
| HU (high dose) | 500 | 1.39 ± 0.18 | 0.78 ± 0.06 | 0.43 ± 0.04 | 0.99 ± 0.01 * |
| Positive control | 500 | 1.77 ± 0.18 | 0.91 ± 0.22 | 0.50 ± 0.06 | 1.11 ± 0.07 ** |
| Female | |||||
| Normal control | - | 1.89 ± 0.13 | 0.72 ± 0.03 | 0.41 ± 0.03 | 1.20 ± 0.09 |
| Hyperlipidemia | - | 2.25 ± 0.47 Δ | 1.21 ± 0.09 Δ | 0.60 ± 0.05 Δ | 0.84 ± 0.25 Δ |
| U | 250 | 1.63 ± 0.30 * | 0.76 ± 0.08 | 0.38 ± 0.06 | 0.98 ± 0.14 |
| HU (low dose) | 125 | 1.26 ± 0.04 **,# | 0.65 ± 0.04 * | 0.30 ± 0.01 ** | 1.05 ± 0.07 * |
| HU(middle dose) | 250 | 1.26 ± 0.04 **,# | 0.67 ± 0.05 * | 0.32 ± 0.01 | 0.91 ± 0.07 |
| HU (high dose) | 500 | 1.42 ± 0.11 | 0.67 ± 0.07 * | 0.31 ± 0.05 * | 0.91 ± 0.09 |
| Positive control | 500 | 1.75 ± 0.17 | 0.81 ± 0.16 | 0.38 ± 0.02 | 1.15 ± 0.12 ** |
Δ p < 0.05: compared with the normal control group; * p < 0.05: compared with the hyperlipidemia control group; ** p < 0.01: compared with the hyperlipidemia control group; # p < 0.05: compared with the ulvan group.