Table 3.
Ten most upregulated and downregulated mRNAs in the carcinomas compared to the adjacent nontumor tissues by volcano plot
| Probe name | FC Absolute | Regulation | Seqname | Gene symbol | Chromosome | Protein accession | Product |
|---|---|---|---|---|---|---|---|
| ASHG19A3A020207 | 41.58339 | Up | NM_005940 | MMP11 | 22 | NP_005931 | Matrix metallopeptidase 11 (stromelysin 3) |
| ASHG19A3A050427 | 35.78423 | Up | NM_007129 | ZIC2 | 13 | NP_009060 | Zic family member 2 (odd-paired homolog, Drosophila) |
| ASHG19A3A049790 | 34.567513 | Up | NM_033132 | ZIC5 | 13 | NP_149123 | Zic family member 5 (odd-paired homolog, Drosophila) |
| ASHG19A3A030137 | 30.225765 | Up | NM_001126063 | KHDC1L | 6 | NP_001119535 | KH homology domain containing 1-like |
| ASHG19A3A017482 | 26.772041 | Up | NM_001898 | CST1 | 20 | NP_001889 | Cystatin SN |
| ASHG19A3A025453 | 19.727985 | Up | NM_004181 | UCHL1 | 4 | NP_004172 | Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
| ASHG19A3A019550 | 15.542832 | Up | NM_006115 | PRAME | 22 | NP_996839 | Preferentially expressed antigen in melanoma |
| ASHG19A3A045632 | 15.119103 | Up | NM_002421 | MMP1 | 11 | NP_002412 | Matrix metallopeptidase 1 (interstitial collagenase) |
| ASHG19A3A045635 | 14.78575 | Up | NM_002427 | MMP13 | 11 | NP_002418 | Matrix metallopeptidase 13 (collagenase 3) |
| CUST_2_PI426249100 | 14.759951 | Up | NM_017410_Exon2+ | NM_017410 | 12 | ||
| ASHG19A3A031264 | 798.7413 | Down | NM_001010909 | MUC21 | 6 | NP_001010909 | Mucin 21, cell surface associated |
| ASHG19A3A005265 | 319.68326 | Down | NM_022438 | MAL | 2 | NP_071885 | Mal, T-cell differentiation protein |
| ASHG19A3A025361 | 242.24474 | Down | NM_012128 | CLCA4 | 1 | NP_036260 | Chloride channel accessory 4 |
| ASHG19A3A005267 | 176.59032 | Down | NM_022440 | MAL | 2 | NP_071885 | Mal, T-cell differentiation protein |
| ASHG19A3A024262 | 162.92448 | Down | NM_182502 | TMPRSS11B | 4 | NP_872308 | Transmembrane protease, serine 11B |
| ASHG19A3A008290 | 138.02931 | Down | NM_019016 | KRT24 | 17 | NP_061889 | Keratin 24 |
| ASHG19A3A004016 | 106.28888 | Down | NM_002371 | MAL | 2 | NP_071885 | Mal, T-cell differentiation protein |
| ASHG19A3A010362 | 103.64228 | Down | NM_002974 | SERPINB4 | 18 | NP_002965 | Serpin peptidase inhibitor, clade B (ovalbumin), member 4 |
| ASHG19A3A010363 | 103.04679 | Down | NM_006919 | SERPINB3 | 18 | NP_008850 | Serpin peptidase inhibitor, clade B (ovalbumin), member 3 |
| ASHG19A3A053404 | 85.175095 | Down | NM_031948 | PRSS27 | 16 | NP_114154 | Protease, serine 27 |