Table 4.
Results of KEGG pathway analysis of mRNAs differentially expressed in carcinomas vs adjacent nontumor tissues
| Pathway list (selection counts) | Enrichment score | Regulation | Genes |
|---|---|---|---|
| ECM-receptor interaction (14) | 6.271957 | Up | COL1A1, COL1A2, COL4A2, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, FN1, ITGA1, ITGA5, LAMC2, SPP1, THBS2 |
| Focal adhesion (21) | 5.696962 | Up | COL1A1//COL1A2//COL4A2//COL5A2//COL5A3//COL6A1//COL6A2//COL6A3//CTNNB1//FLT1//FN1//ITGA1//ITGA5//LAMC2//MYL9//PDGFB//PRKCA//ROCK2//SPP1//THBS2//VEGFA |
| Melanogenesis (12) | 3.979435 | Up | ADCY1//ADCY6//CAMK2D//CREB3L1//CTNNB1//FZD1//FZD2//FZD7//FZD8//FZD9//PRKACA//PRKCA |
| Amoebiasis (12) | 3.69807 | Up | ADCY1//COL1A1//COL1A2//COL4A2//COL5A2//COL5A3//FN1//GNA11//HSPB1//LAMC2//PRKACA//PRKCA |
| Wnt signaling pathway (14) | 3.388262 | Up | CAMK2D//CTNNB1//FZD1//FZD2//FZD7//FZD8//FZD9//NFATC1//NKD2//PORCN//PPP2CB//PRKACA//PRKCA//ROCK2 |
| Dilated cardiomyopathy (10) | 3.090323 | Up | ADCY1//ADCY6//ITGA1//ITGA5//PRKACA//SGCB//SGCD//TNNI3//TPM1//TPM2 |
| Protein digestion and absorption (9) | 2.899216 | Up | COL1A1//COL1A2//COL4A2//COL5A2//COL5A3//COL6A1//COL6A2//COL6A3//COL9A2 |
| Basal cell carcinoma (7) | 2.701192 | Up | CTNNB1//FZD1//FZD2//FZD7//FZD8//FZD9//GLI3 |
| Vascular smooth muscle contraction (10) | 2.33321 | Up | ADCY1//ADCY6//ARHGEF1//GNA11//KCNMA1//MYL6B//MYL9//PRKACA//PRKCA//ROCK2 |
| Chagas disease (American trypanosomiasis) (9) | 2.158455 | Up | ADCY1//CALR//CCL3//CCL3L1//CCL3L3//GNA11//MAPK12//PPP2CB//SERPINE1 |
| Pathogenic Escherichia coli infection (6) | 2.051097 | Up | CTNNB1//EZR//PRKCA//ROCK2//TUBB4//YWHAZ |
| Chemokine signaling pathway (13) | 2.040568 | Up | ADCY1//ADCY6//CCL11//CCL3//CCL3L1//CCL3L3//CCL4//CCL4L1//CXCR2//GNB4//PRKACA//ROCK2//XCL1 |
| Pyruvate metabolism (5) | 1.980173 | Up | ACSS1//AKR1B1//ALDH1B1//PC//PKM2 |
| Cholinergic synapse (9) | 1.954947 | Up | ADCY1//ADCY6//CAMK2D//CHRNA3//CREB3L1//GNA11//GNB4//PRKACA//PRKCA |
| Retrograde endocannabinoid signaling (8) | 1.73084 | Up | ADCY1//ADCY6//GABRA1//GABRA5//GNB4//MAPK12//PRKACA//PRKCA |
| Hypertrophic cardiomyopathy (7) | 1.724737 | Up | ITGA1//ITGA5//SGCB//SGCD//TNNI3//TPM1//TPM2 |
| Salmonella infection (7) | 1.648289 | Up | CCL3//CCL3L1//CCL3L3//CCL4//CCL4L1//MAPK12//ROCK2 |
| Gap junction (7) | 1.575761 | Up | ADCY1//ADCY6//GNA11//PDGFB//PRKACA//PRKCA//TUBB4 |
| GABAergic synapse (7) | 1.575761 | Up | ADCY1//ADCY6//GABRA1//GABRA5//GNB4//PRKACA//PRKCA |
| Salivary secretion (7) | 1.575761 | Up | ADCY1//ADCY6//ATP2B4//CST1//KCNMA1//PRKACA//PRKCA |
| Bile secretion (6) | 1.544129 | Up | ABCC4//ADCY1//ADCY6//AQP9//PRKACA//SLC27A5 |
| Oocyte meiosis (8) | 1.514502 | Up | ADCY1//ADCY6//ANAPC11//CAMK2D//MAPK12//PPP2CB//PRKACA//YWHAZ |
| Morphine addiction (7) | 1.506877 | Up | ADCY1//ADCY6//GABRA1//GABRA5//GNB4//PRKACA//PRKCA |
| Gastric acid secretion (6) | 1.467153 | Up | ADCY1//ADCY6//CAMK2D//EZR//PRKACA//PRKCA |
| Leukocyte transendothelial migration (8) | 1.436409 | Up | CTNNB1//EZR//MAPK12//MMP9//MYL9//PRKCA//ROCK2//SIPA1 |
| Arginine and proline metabolism (5) | 1.415061 | Up | ALDH1B1//GAMT//NAGS//P4HA1//PYCR1 |
| Pathways in cancer (17) | 1.386872 | Up | BIRC5//COL4A2//CTNNB1//FGFR1//FN1//FZD1//FZD2//FZD7//FZD8//FZD9//GLI3//LAMC2//MMP1//MMP9//PDGFB//PRKCA//VEGFA |
| Regulation of actin cytoskeleton (12) | 1.336989 | Up | ABI2//ARHGEF1//EZR//FGFR1//FN1//ITGA1//ITGA5//MYL9//PDGFB//RDX//ROCK2//SSH1 |
| GnRH signaling pathway (7) | 1.319729 | Up | ADCY1//ADCY6//CAMK2D//GNA11//MAPK12//PRKACA//PRKCA |
| Tight junction (13) | 2.943522 | Down | CGN//CLDN3//CLDN7//EPB41L1//HRAS//LLGL2//MAGI3//MYL12B//MYL5//PPP2R1B//PRKCH//TJP1//TJP2 |
| African trypanosomiasis (6) | 2.66711 | Down | HBA1//HBA2//HBB//HPR//IL18//SELE |
| Peroxisome (9) | 2.65428 | Down | ACAA1//ACOX1//ACOX3//CROT//EPHX2//FAR1//HMGCL//HSD17B4//MLYCD |
| Drug metabolism-other enzymes (7) | 2.597677 | Down | CES2//CYP3A4//CYP3A43//CYP3A5//CYP3A7//DPYD//TK2 |
| Drug metabolism-cytochrome P450 (8) | 2.311757 | Down | ALDH3B2//CYP3A4//CYP3A43//CYP3A5//CYP3A7//FMO4//MAOA//MGST2 |
| Malaria (6) | 1.964824 | Down | HBA1//HBA2//HBB//IL18//KLRB1//SELE |
| Nicotinate and nicotinamide metabolism (4) | 1.839552 | Down | C9ORF95//NAPRT1//NT5C3//PNP |
| Steroid hormone biosynthesis (6) | 1.775109 | Down | CYP3A4//CYP3A43//CYP3A5//CYP3A7//CYP7B1//SRD5A3 |
| Histidine metabolism (4) | 1.727958 | Down | ALDH3B2//AMDHD1//FTCD//MAOA |
| Linoleic acid metabolism (4) | 1.675968 | Down | CYP3A4//CYP3A43//CYP3A5//CYP3A7 |
| Steroid biosynthesis (3) | 1.633233 | Down | DHCR24//NSDHL//TM7SF2 |
| Phenylalanine metabolism (3) | 1.565825 | Down | ALDH3B2//GOT1//MAOA |
| Influenza A (12) | 1.558672 | Down | CREBBP//FDPS//IL18//MAPK8//NXF1//PRSS2//PRSS3//RAF1//RNASEL//TLR3//TLR7//TRIM25 |
| Metabolism of xenobiotics by cytochrome P450 (7) | 1.550808 | Down | ALDH3B2//CBR3//CYP3A4//CYP3A43//CYP3A5//CYP3A7//MGST2 |
| Glycolysi/gluconeogenesis (6) | 1.488156 | Down | ALDH3B2//BPGM//DLAT//LDHC//PGAM2//PGM2 |
| Alpha-Linolenic acid metabolism (3) | 1.38884 | Down | ACAA1//ACOX1//ACOX3 |
| Terpenoid backbone biosynthesis (3) | 1.38884 | Down | FDPS//HMGCR//IDI1 |
| Biosynthesis of unsaturated fatty acids (3) | 1.38884 | Down | ACAA1//ACOX1//ACOX3 |
| Neurotrophin signaling pathway (9) | 1.341531 | Down | GAB1//HRAS//MAP3K5//MAPK7//MAPK8//NTRK1//RAF1//RPS6KA1//SORT1 |